circRNA basic information
circBase ID: hsa_circ_0018082
Name: hsa_circ_ZEB1
Synonym: circ-ZEB1
Host Gene: ZEB1
Genomic location(hg19): chr10:31607423-31676195:+
Genomic location(hg38): chr10:31318494-31387266:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue; adjacent tissues; lung tissue
Cell lines:

NCI-H1299; H1650; PC9; A549; Beas-2B; Luc-A549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: EIF5A
Associated microRNA: miR-491-5p
Biological function: promotes NSCLC cell proliferation, migration/invasion, tumor growth and lung metastasis
Molecular mechanism: ceRNA mechanism: circ-ZEB1 sponges miR-491-5p to increase EIF5A expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

FISH / smFISH; RT-qPCR; Luciferase Reporter Assay; Transwell Assay; EdU Staining; CCK8; Transfection; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis
Clinical significance:

higher expression of circ-ZEB1 may be linked to tumor invasion
Description:

circ-ZEB1 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. Functionally, circ-ZEB1 promotes NSCLC proliferation, migration/invasion, tumor growth, and lung metastasis by sponging miR-491-5p to increase EIF5A expression (circ-ZEB1/miR-491-5p/EIF5A axis).
Confidence score:

0.6829
Other information
Title:

circ-ZEB1 Enhances NSCLC Metastasis and Proliferation by Modulating the miR-491-5p/EIF5A Axis.

Journal: Analytical cellular pathology (Amsterdam)
Published: 2025
PubMed ID: 39802932
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -