| Expression pattern: |
DN |
| Associated gene: |
predicted mRNAs |
| Associated microRNA: |
miR-181b-5p, miR-181c-5p, miR-181d-5p, miR-181a-5p, miR-329-5p |
| Biological function: |
Significantly down-regulated in HBV-related HCC tissues; may play an important role in the development of HCC and may represent a potential biomarker for HCC early diagnosis and prognosis. |
| Molecular mechanism: |
Predicted interaction with miRNA181 family and downstream miRNA/mRNA network; biological effects may be achieved by binding miRNAs. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
may represent potential novel biomarkers for HCC early diagnosis and prognosis |
| Description: |
CircRNA_101764 was significantly down-regulated in HBV-related HCC tissues and was validated by qRT-PCR. It was the largest node in the predicted circRNA/miRNA co-expression network, mainly interacting with the miR-181 family, suggesting a potential role in HCC development through miRNA-mediated regulatory networks. |
| Confidence score: |
0.5135 |