| Expression pattern: |
UP |
| Associated gene: |
predicted mRNAs |
| Associated microRNA: |
miR-525-5p, miR-544a, miR-345-3p, miR-577, miR-587 |
| Biological function: |
Aberrantly up-regulated in HBV-related HCC tissues; may represent a potential novel biomarker for HCC early diagnosis and prognosis. |
| Molecular mechanism: |
Predicted circRNA/miRNA interactions and downstream miRNA/mRNA network; biological effects may be achieved by binding miRNAs. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
may represent potential novel biomarkers for HCC early diagnosis and prognosis |
| Description: |
hsa_circRNA 100381/circRNA_100381 was significantly up-regulated in HBV-related HCC tissues compared with adjacent non-tumorous tissues and was validated by qRT-PCR. The study predicted interactions with five miRNAs and downstream mRNAs, suggesting a possible ceRNA-related role and potential biomarker value for HCC diagnosis and prognosis. |
| Confidence score: |
0.5135 |