| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-486-5p / miR-486 |
| Biological function: |
promotes proliferation, colony formation, migration and invasion; inhibits apoptosis |
| Molecular mechanism: |
circHUWE1 acts as a miRNA sponge for miR-486 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Sanger Sequencing; FISH / smFISH; Transfection; Luciferase Reporter Assay; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circHUEW1 was significantly associated with lymphovascular invasion, lymph node metastasis, distant metastasis, and TNM stage; ROC AUC was 0.732 indicating potential diagnostic biomarker value for CRC |
| Description: |
circHUWE1 is up-regulated in colorectal cancer tissues and mainly localized in the cytoplasm. Functionally, circHUWE1 promotes CRC cell proliferation, colony formation, migration and invasion and suppresses apoptosis, at least in part by sponging miR-486; it also shows potential diagnostic value (ROC AUC 0.732) and correlates with adverse clinicopathologic features. |
| Confidence score: |
0.8162 |