| Expression pattern: |
DN |
| Associated gene: |
APC2, Wnt/b-catenin pathway, MYC, SOX4, nucleus b-catenin |
| Associated microRNA: |
miR-1205 |
| Biological function: |
Acts as a tumor suppressor in osteosarcoma; overexpression suppresses OS cell proliferation, migration and invasion, promotes apoptosis, and impairs tumor growth in vivo. |
| Molecular mechanism: |
hsa_circ_0002052 functions as a miR-1205 sponge, releases miR-1205-mediated inhibition of APC2, and suppresses activation of the Wnt/b-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0002052 could serve as a prognostic biomarker for OS patients; lower levels were associated with worse overall and progression-free survival. |
| Description: |
hsa_circ_0002052 is down-regulated in osteosarcoma tissues and cell lines and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion and xenograft growth while promoting apoptosis. Mechanistically, it sponges miR-1205 to upregulate APC2 and inhibit Wnt/beta-catenin signaling, and its higher expression is associated with better patient survival. |
| Confidence score: |
0.7486 |