| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Promotes NSCLC cell proliferation, cell cycle progression, migration and invasion, and regulates EMT; knockdown restrains proliferation, induces cell cycle arrest, and impairs migration and invasion. |
| Molecular mechanism: |
hsa_circ_0079530 promotes proliferation and cell cycle progression through inducing cell cycle-related proteins, and promotes invasion and migration through regulating EMT; the precise mechanism was not fully elucidated. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0079530 expression was correlated with tumor size and lymph node metastasis; ROC analysis suggested diagnostic value for differentiating NSCLC tissues from normal controls; authors suggested potential as a prognosis predictor and therapeutic target. |
| Description: |
hsa_circ_0079530 is up-regulated in NSCLC tissues and cell lines and is associated with tumor size and lymph node metastasis. Functional knockdown experiments indicate that it acts as an oncogenic circRNA by promoting proliferation, cell cycle progression, migration, invasion and EMT-related changes, while ROC analysis suggests potential diagnostic biomarker value. |
| Confidence score: |
0.713 |