| Expression pattern: |
UP |
| Associated gene: |
CDK1, Ago2 |
| Associated microRNA: |
miR-489-3p |
| Biological function: |
CircCDK1 promotes Tamoxifen resistance, cell proliferation, tumor growth and cell survival in breast cancer; circCDK1 knockdown strengthens Tamoxifen sensitivity, inhibits proliferation and promotes apoptosis. |
| Molecular mechanism: |
CircCDK1 acts as a miR-489-3p sponge and positively regulates CDK1 expression, thereby governing Tamoxifen resistance and breast cancer cell growth and survival. |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircCDK1 was highly expressed in Tamoxifen-resistant tumor tissues and may provide a biomarker or therapeutic strategy for overcoming Tamoxifen resistance in estrogen receptor-positive breast cancer. |
| Description: |
CircCDK1 is up-regulated in Tamoxifen-resistant breast cancer tissues and cells. It promotes Tamoxifen resistance, proliferation and survival by sponging miR-489-3p to increase CDK1 expression, while circCDK1 knockdown enhances Tamoxifen sensitivity and suppresses tumor growth in vitro and in vivo. |
| Confidence score: |
0.8571 |