circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011962
MONDO name: endometrial cancer
Disease details: endometrial cancer / EC
Disease DO ID:
 1380
Disease MeSH ID:
 -
Disease NCIt ID:
 C27815
Disease ICD11 ID:
 -
Disease OMIM ID:
 608089
Species: Human
Species details: Homo sapiens
Tissue specimen:

EC tissues; paired nontumor tissues; adjacent tissue samples
Cell lines:

RL95-2; HEC-1-A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: miR-21 gene
Associated microRNA: miR-21
Biological function: circFAT1 promotes endometrial cancer cell stemness.
Molecular mechanism: circFAT1 upregulates miR-21 by decreasing methylation of the miR-21 gene, thereby increasing endometrial cancer cell stemness.
Biological pathway or process:

stemness (promotes); other pathway/process (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Transfection; MSP (Methylation-Specific PCR); Flow Cytometry（Non-apoptosis/cycle）
Clinical significance:

-
Description:

circFAT1 is upregulated in endometrial cancer tissues and functions as an oncogenic circRNA in this study. It promotes EC cell stemness by increasing miR-21 expression through reduced methylation of the miR-21 gene, and miR-21 inhibition suppresses the stemness-promoting effect of circFAT1.
Confidence score:

0.6166
Other information
Title:

Overexpression of circRNA circFAT1 in Endometrial Cancer Cells Increases Their Stemness by Upregulating miR-21 Through Methylation.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2022
PubMed ID: 34314629
Study type:

combined biological and clinical study
Data availability: available on request from the corresponding author; not publicly available
Code availability: -