| Expression pattern: |
UP |
| Associated gene: |
METTL3, YTHDF2, FMR1, AGO2 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation and migration of prostate cancer cells |
| Molecular mechanism: |
m6A modification increases circ0030568 stability via METTL3 and YTHDF2; circ0030568 binds/interacts with FMR1 and upregulates FMR1; curcumin inhibits PCa by downregulating YTHDF2-mediated circ0030568 stability |
| Biological pathway or process: |
m6A modification (promotes); proliferation (promotes); migration (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; MeRIP / MeRIP-seq; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Wound Healing Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ0030568 may act as a promising biomarker and an attractive target for PCa treatment |
| Description: |
circ0030568 is up-regulated and m6A-modified in prostate cancer cells, where it promotes proliferation and migration. METTL3 installs m6A on circ0030568 and the reader YTHDF2 increases circ0030568 stability; circ0030568 in turn upregulates FMR1. Curcumin suppresses PCa cell proliferation/migration by inhibiting YTHDF2 and reducing METTL3/YTHDF2-driven circ0030568 stability and downstream FMR1. |
| Confidence score: |
0.7884 |