| Expression pattern: |
UP |
| Associated gene: |
Snail, ADAM9 |
| Associated microRNA: |
miR-153-3p |
| Biological function: |
circRNA_0084043 promotes melanoma cell proliferation, invasion, migration, tumor growth and metastasis, and functions as an oncogene in melanoma. |
| Molecular mechanism: |
circRNA_0084043 acts as a ceRNA/miRNA sponge for miR-153-3p, thereby releasing and up-regulating Snail expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRNA_0084043 expression was significantly associated with clinical stage and was an independent risk factor of overall survival in melanoma patients; circRNA_0084043 may serve as a potential therapeutic target for melanoma patients. |
| Description: |
circRNA_0084043 is up-regulated in malignant melanoma tissues and melanoma cell lines, and high expression is associated with poorer overall survival. Functionally, it promotes melanoma proliferation, migration, invasion, metastasis and xenograft tumor growth. Mechanistically, circRNA_0084043 acts as a sponge for miR-153-3p to release and up-regulate Snail expression, supporting an oncogenic circRNA_0084043/miR-153-3p/Snail axis. |
| Confidence score: |
0.8424 |