circRNA basic information
circBase ID: hsa_circ_0058189
Name: hsa_circ_SMRACAL1
Synonym: circ_0058189
Host Gene: SMRACAL1
Genomic location(hg19): chr2:217329319-217340174:+
Genomic location(hg38): chr2:216464596-216475451:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; plasma
Cell lines:

HepG2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EOGT
Associated microRNA: hsa-miR-130a-3p
Biological function: Promotes HCC progression and sorafenib resistance.
Molecular mechanism: Acts as a molecular sponge for hsa-miR-130a-3p to derepress EOGT (ceRNA model) in an exosome-associated context.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); drug resistance (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Potential dual diagnostic and therapeutic resistance biomarker (upregulated in HCC tissues, plasma, and exosomes from sorafenib-resistant cells).
Description:

hsa_circ_0058189 is upregulated in HCC tissues and patient plasma and is enriched in exosomes from sorafenib-resistant HepG2 cells. It is proposed to promote HCC progression and sorafenib resistance by sponging hsa-miR-130a-3p, thereby relieving repression of EOGT in a ceRNA axis.
Confidence score:

0.1768
Other information
Title:

Migrasome Marker Epidermal Growth Factor Domain-Specific O-GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis in Hepatocellular Carcinoma Progression and Sorafenib Resistance.

Journal: Biomedicines
Published: 2025
PubMed ID: 40299340
Study type:

combined biological and clinical study
Data availability: GSE101850; GSE166678; GSE97332
Code availability: -