| Expression pattern: |
UP |
| Associated gene: |
EIF4A1 |
| Associated microRNA: |
miR-489-3p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration/invasion and tumor growth; circDLST overexpression attenuates AS-IV-induced anti-tumor effects. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-489-3p, thereby upregulating EIF4A1; involved in AS-IV-mediated inhibition of GC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circDLST might be used as a diagnostic target for GC and a potential biomarker in the treatment process of AS-IV for GC. |
| Description: |
circDLST is up-regulated in gastric cancer cells and promotes malignant phenotypes. AS-IV suppresses GC proliferation and metastasis partly by downregulating circDLST, which sponges miR-489-3p to increase EIF4A1 expression (circDLST/miR-489-3p/EIF4A1 ceRNA axis). |
| Confidence score: |
0.7092 |