| Expression pattern: |
UP |
| Associated gene: |
ZNF121, MYC |
| Associated microRNA: |
miR-4302 |
| Biological function: |
Promotes lung cancer cell proliferation, colony formation, invasion, and tumor growth; knockdown suppresses proliferation and invasion in vitro and delays tumor growth in vivo. |
| Molecular mechanism: |
hsa_circRNA_103809 acts as a sponge for miR-4302, promotes ZNF121 expression, and thereby enhances MYC protein levels to drive lung cancer progression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; Co-IP; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circRNA_103809 could serve as a prognostic biomarker for patients with lung cancer; higher expression was associated with lower survival. |
| Description: |
hsa_circRNA_103809 is up-regulated in lung cancer tissues and cell lines and high expression is associated with poorer survival. Functionally, it promotes lung cancer cell proliferation, colony formation, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-4302 to increase ZNF121 expression, which elevates MYC protein levels and drives lung cancer progression. |
| Confidence score: |
0.7548 |