| Expression pattern: |
DN |
| Associated gene: |
CAPZA1, MBNL1, AGO2 |
| Associated microRNA: |
miR-589 |
| Biological function: |
inhibits proliferation, invasion and migration; promotes apoptosis; suppresses tumor growth in xenograft models |
| Molecular mechanism: |
Exosome-delivered circSTAU2 acts as a miRNA sponge for miR-589 to relieve repression of CAPZA1; MBNL1 promotes circSTAU2 circularization/expression by binding STAU2 pre-mRNA |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
Lower hsa_circ_0001811 expression was associated with TNM III-IV stage in gastric cancer patients. |
| Description: |
circSTAU2 (hsa_circ_0001811) is down-regulated in gastric cancer and functions as a tumor suppressor. It is packaged into exosomes and, after uptake by recipient cells, sponges miR-589 to de-repress CAPZA1, thereby inhibiting proliferation, migration/invasion and promoting apoptosis; MBNL1 promotes circSTAU2 biogenesis/expression upstream. |
| Confidence score: |
0.8354 |