| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-145-5p, hsa-miR-520f-3p, hsa-miR-1178-3p, hsa-miR-876-3p |
| Biological function: |
Differentially expressed in lung adenocarcinoma and proposed as a potential lung adenocarcinoma-related circRNA/biomarker candidate; no functional cell phenotype assay was reported. |
| Molecular mechanism: |
Predicted circRNA-miRNA-protein coding gene interaction network; hsa_circRNA_100421 was predicted to sponge hsa-miR-145-5p, hsa-miR-520f-3p, hsa-miR-1178-3p and hsa-miR-876-3p. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential lung adenocarcinoma-related circRNA and potential biomarker candidate; FFPE specimens may be used for circRNA biomarker discovery. |
| Description: |
hsa_circRNA_100421 was up-regulated in lung adenocarcinoma tissues and its expression change was confirmed by qRT-PCR. The study predicted that it may participate in a circRNA-miRNA-mRNA regulatory network, including predicted interactions with hsa-miR-145-5p, hsa-miR-520f-3p, hsa-miR-1178-3p and hsa-miR-876-3p. |
| Confidence score: |
0.5135 |