| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Knockdown of hsa_circ_0072309 inhibited A549 cell proliferation and promoted apoptosis; the authors suggested an oncogenetic role in lung adenocarcinoma. |
| Molecular mechanism: |
Not mechanistically defined; functional assays showed effects on proliferation and apoptosis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; ROC Analysis; Survival Analysis |
| Clinical significance: |
Low expression was associated with advanced TNM stage, lymph node metastasis, smoking, diagnostic AUC, and shorter overall survival and disease-free rates. |
| Description: |
hsa_circ_0072309 was down-regulated in lung adenocarcinoma serum and tissues and showed diagnostic and prognostic significance. Lower expression correlated with aggressive clinical features and poorer survival, while knockdown reduced A549 proliferation and promoted apoptosis, suggesting a pro-tumor functional role. |
| Confidence score: |
0.6155 |