| Expression pattern: |
DN |
| Associated gene: |
RBMS1, HuR, AKAP12 |
| Associated microRNA: |
- |
| Biological function: |
inhibits migration and invasion; inhibits metastasis |
| Molecular mechanism: |
acts as a protein scaffold enhancing RBMS1-HuR binding and increasing AKAP12 mRNA stability/expression |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); mRNA stability (promotes) |
| Detected method: |
Q
H
S
M
|
| Validation methods: |
circRNA-seq; Microarray; RT-qPCR; Clinical Sample Validation; ISH (In Situ Hybridization); Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; Western Blot; CLIP; RNA-seq; Transfection; Transwell Assay; Wound Healing Assay; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; Survival Analysis |
| Clinical significance: |
low expression of circEXOC6B predicted advanced pT stage and worse prognosis |
| Description: |
circEXOC6B is down-regulated in prostate cancer and acts as a metastasis suppressor. It functions as a protein scaffold to enhance RBMS1-HuR complex formation, increasing AKAP12 mRNA stability and AKAP12 expression, thereby inhibiting migration, invasion, and lung metastasis. |
| Confidence score: |
0.8805 |