| Expression pattern: |
UP |
| Associated gene: |
ERBB3 |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
promotes proliferation, angiogenesis, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponging of miR-1287-5p leading to increased ERBB3 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; EdU Staining; MTT; Tube Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis; Microarray |
| Clinical significance: |
- |
| Description: |
circ_PLXND1 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, angiogenesis, migration, invasion and tumor growth) and inhibits apoptosis by sponging miR-1287-5p to upregulate ERBB3. |
| Confidence score: |
0.7955 |