circRNA basic information
circBase ID: hsa_circ_0027446
Name: hsa_circ_HMGA2
Synonym: circRNA High Mobility Group AT-hook 2
Host Gene: HMGA2
Genomic location(hg19): chr12:66221780-66232349:+
Genomic location(hg38): chr12:65828000-65838569:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; normal control tissues; tumor tissues
Cell lines:

BEAS-2B; Calu-3; Calu-6; A549; H1299
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGA2, Ago2, HK2, LDHA
Associated microRNA: miR-331-3p
Biological function: CircHMGA2 promotes NSCLC cell proliferation, migration, invasion, metastasis, tumorigenesis and glycolytic metabolism.
Molecular mechanism: CircHMGA2 acts as a miR-331-3p sponge to upregulate HMGA2, thereby regulating NSCLC progression and glycolysis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

Actinomycin D / DRB Stability Assay; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circHMGA2 level might be related to NSCLC metastasis and poor prognosis, and circHMGA2 could be used as a prognostic marker and potential tumor marker for diagnosis and treatment.
Description:

CircHMGA2 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with metastasis and poor prognosis. Functionally, circHMGA2 promotes NSCLC proliferation, migration, invasion, tumorigenesis and glycolysis. Mechanistically, circHMGA2 sponges miR-331-3p to increase HMGA2 expression, forming the circHMGA2/miR-331-3p/HMGA2 regulatory axis.
Confidence score:

0.8568
Other information
Title:

CircRNA High Mobility Group At-hook 2 regulates cell proliferation, metastasis and glycolytic metabolism of nonsmall cell lung cancer by targeting miR-331-3p to upregulate High Mobility Group At-hook 2.

Journal: Anti-cancer drugs
Published: 2023
PubMed ID: 36066399
Study type:

combined biological and clinical study
Data availability: the datasets used and analyzed during the current study are available from the corresponding author upon reasonable request
Code availability: -