| Expression pattern: |
DN |
| Associated gene: |
FBXW7 |
| Associated microRNA: |
miR-223-3p |
| Biological function: |
Inhibits ovarian cancer progression by repressing proliferation, migration and invasion, inducing G0/G1 cell-cycle arrest, and reducing lung metastasis in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-223-3p, thereby upregulating FBXW7. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); cell cycle (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ-BNC2 expression was associated with advanced FIGO stage, lymph node metastasis, and shorter overall survival; circ-BNC2 may be a potential biomarker for OC therapy. |
| Description: |
circ-BNC2 (hsa_circ_0008732) is down-regulated in ovarian cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-223-3p to increase FBXW7 expression, thereby inhibiting proliferation, migration/invasion, cell-cycle progression, and metastasis. |
| Confidence score: |
0.7759 |