| Expression pattern: |
UP |
| Associated gene: |
ZEB1, Ago2 |
| Associated microRNA: |
miR-152 |
| Biological function: |
promotes cell migration and invasion; inhibits apoptosis; promotes cell metastasis |
| Molecular mechanism: |
circKIF4A acts as a miRNA sponge for miR-152 to upregulate ZEB1 (ceRNA-like mechanism). |
| Biological pathway or process: |
migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); EMT (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circKIF4A level was associated with tumor size and TNM stage in breast cancer patients. |
| Description: |
circKIF4A is upregulated in breast cancer tissues and cells and promotes migration/invasion while inhibiting apoptosis. Mechanistically, circKIF4A sponges miR-152 to relieve repression of ZEB1, forming a circKIF4A-miR-152-ZEB1 axis that drives malignant phenotypes. |
| Confidence score: |
0.6996 |