circRNA basic information
circBase ID: hsa_circ_0007385
Name: hsa_circ_MEMO1
Synonym: -
Host Gene: MEMO1
Genomic location(hg19): chr2:32142994-32157204:-
Genomic location(hg38): chr2:31917925-31932135:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Induced by carboplatin but completely inhibited by combined carboplatin+pemetrexed treatment; discussed as potentially associated with resistance to platinum based therapies.
Molecular mechanism: Not specified in this study (mechanistic details described only from literature).
Biological pathway or process:

drug resistance (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0007385 shows opposite responses depending on regimen: it increases after carboplatin alone but is completely inhibited by combined carboplatin+pemetrexed in A549 cells. The authors suggest this pattern may relate to platinum-based drug resistance.
Confidence score:

0.279
Other information
Title:

Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.

Journal: Asian Pacific journal of cancer prevention : APJCP
Published: 2024
PubMed ID: 38918678
Study type:

biological research
Data availability: -
Code availability: -