| Expression pattern: |
UP |
| Associated gene: |
FZD5 mRNA, FZD5, beta-catenin, Cyclin D1 |
| Associated microRNA: |
miR-1324 |
| Biological function: |
circ_0067934 promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0067934 functions through a ceRNA-like miR-1324/FZD5/Wnt/beta-catenin signaling axis, suppressing miR-1324 and activating FZD5/Wnt/beta-catenin signaling. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0067934 expression was positively correlated with HCC TNM stage and HCC severity, and higher expression correlated with poorer prognosis. |
| Description: |
circ_0067934 is up-regulated in HCC tissues and cell lines and its high expression is associated with advanced disease and poor prognosis. Functionally, circ_0067934 promotes proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it suppresses miR-1324, thereby increasing FZD5 and activating the Wnt/beta-catenin pathway. |
| Confidence score: |
0.7373 |