circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_TADA2A
Synonym: circ-TADA2A
Host Gene: TADA2A
Genomic location(hg19): chr17:35797838-35800763:+
Genomic location(hg38): chr17:37437737-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006047
MONDO name: pancreatic adenocarcinoma
Disease details: pancreatic adenocarcinoma
Disease DO ID:
 4074
Disease MeSH ID:
 -
Disease NCIt ID:
 C8294
Disease ICD11 ID:
 1663659989
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PAAD tissue; normal pancreatic tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-214
Biological function: May modulate PAAD biogenesis, growth and progression via a circRNA/miRNA axis (circ-TADA2A/hsa-miR-214).
Molecular mechanism: ceRNA-like circRNA/miRNA interaction (circ-TADA2A with hsa-miR-214); downstream targets not specified.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-TADA2A (hsa_circ_0043278) is up-regulated in PAAD and included in the constructed ceRNA network. The paper proposes a circ-TADA2A/hsa-miR-214 axis potentially involved in PAAD growth and progression, based on database-driven network analyses.
Confidence score:

0.1768
Other information
Title:

CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.

Journal: Aging
Published: 2019
PubMed ID: 31584877
Study type:

bioinformatics study
Data availability: GSE79634; GSE69362; GSE60980
Code availability: -