circRNA basic information
circBase ID: hsa_circ_0069865
Name: hsa_circ_LPHN3
Synonym: circLPHN3
Host Gene: LPHN3
Genomic location(hg19): chr4:62800557-62910267:+
Genomic location(hg38): chr4:61934839-62044549:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal colorectal tissues; cancer and paracancer tissue samples
Cell lines:

FHC; LoVo; Caco2; HCT8; SW480
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: LDB2
Associated microRNA: miR-142-5p
Biological function: Acts as a tumor suppressor in CRC; overexpression curbs CRC cell growth, proliferation, migration, and invasion; lower expression is associated with lymph node metastasis, advanced TNM stage, and poor prognosis.
Molecular mechanism: circLPHN3 negatively regulates miR-142-5p, and miR-142-5p targets LDB2; circLPHN3 suppresses CRC cellular processes through a circLPHN3/miR-142-5p/LDB2-related ceRNA mechanism.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model
Clinical significance:

CircLPHN3 is associated with TNM stage and lymph node metastasis; low circLPHN3 predicts shorter overall survival and is an independent predictor of CRC prognosis.
Description:

circLPHN3 (hsa_circ_0069865), derived from LPHN3, is downregulated in colorectal cancer tissues and cell lines. It functions as a tumor suppressor by negatively regulating miR-142-5p, thereby curbing CRC cell proliferation, migration, and invasion, with LDB2 identified as a downstream target of miR-142-5p. Clinically, reduced circLPHN3 is associated with advanced TNM stage, lymph node metastasis, and shorter survival, supporting its value as a prognostic biomarker.
Confidence score:

0.7588
Other information
Title:

CircLPHN3 correlates with prognosis in colorectal cancer and regulates cellular processes by targeting miR-142-5p.

Journal: The International journal of biological markers
Published: 2024
PubMed ID: 39420826
Study type:

combined biological and clinical study
Data availability: GSE121842; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE121842
Code availability: -