| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for colorectal cancer; negatively correlated with CRC pathological differentiation. |
| Molecular mechanism: |
Unknown; the study measured differential expression and diagnostic value, but did not determine how hsa_circ_0001649 regulates colorectal cancer initiation or progression. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Down-regulated hsa_circ_0001649 showed negative correlation with CRC pathological differentiation and potential diagnostic value, with ROC AUC 0.857, sensitivity 0.828, and specificity 0.781. |
| Description: |
This study reports that hsa_circ_0001649 is down-regulated in colorectal cancer tissues, HCT116 cells, and patient serum. Its expression is negatively correlated with pathological differentiation and shows potential diagnostic value for CRC, but the molecular mechanism was not determined. |
| Confidence score: |
0.5958 |