circRNA basic information
circBase ID: hsa_circ_0008039
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr7:716865-751164:-
Genomic location(hg38): chr7:677228-711527:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: Breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; matched normal tissues; xenograft tumors
Cell lines:

MCF-7; SKBR3; MCF10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CBX4
Associated microRNA: miR-515-5p
Biological function: Promotes breast cancer cell proliferation, migration, invasion and tumor growth in vivo; knockdown suppresses proliferation, migration, invasion and xenograft tumor growth.
Molecular mechanism: hsa_circ_0008039 acts as a ceRNA sponge for miR-515-5p to upregulate CBX4 expression, thereby promoting breast cancer development.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for breast cancer treatment.
Description:

hsa_circ_0008039 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer cell proliferation, migration, invasion and xenograft tumor growth by acting as a ceRNA for miR-515-5p and increasing CBX4 expression, suggesting potential therapeutic relevance.
Confidence score:

0.7277
Other information
Title:

Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32141558
Study type:

combined biological and clinical study
Data availability: -
Code availability: -