circRNA basic information
circBase ID: hsa_circ_0007367
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: UBAP2
Genomic location(hg19): chr9:33948371-33956144:-
Genomic location(hg38): chr9:33948373-33956146:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006047
MONDO name: pancreatic adenocarcinoma
Disease details: pancreatic adenocarcinoma
Disease DO ID:
 4074
Disease MeSH ID:
 -
Disease NCIt ID:
 C8294
Disease ICD11 ID:
 1663659989
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PAAD tissue; normal pancreatic tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCR4, HIF1A, ZEB1, SDC1
Associated microRNA: hsa-miR-494
Biological function: Promotes pancreatic tumorigenesis; may modulate immune-cell infiltration and immune escape via the circ-UBAP2/hsa-miR-494 network affecting hub genes.
Molecular mechanism: ceRNA mechanism in which circ-UBAP2 suppresses hsa-miR-494, thereby regulating hub-gene expression (CXCR4, HIF1A, ZEB1, SDC1).
Biological pathway or process:

NF-kappaB (other); PI3K/AKT (other); Wnt/beta-catenin (other); ceRNA regulation (promotes); immune regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-UBAP2 (hsa_circ_0007367) is up-regulated in PAAD and is proposed to function in a ceRNA network by inhibiting hsa-miR-494, thereby increasing expression of hub genes such as CXCR4, HIF1A, ZEB1 and SDC1. The circUBAP2-mediated network is linked to immune-cell infiltration and immune escape features in PAAD.
Confidence score:

0.1768
Other information
Title:

CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.

Journal: Aging
Published: 2019
PubMed ID: 31584877
Study type:

bioinformatics study
Data availability: GSE79634; GSE69362; GSE60980
Code availability: -