circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1AS
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005076
MONDO name: periodontitis
Disease details: periodontitis
Disease DO ID:
 824, 9893
Disease MeSH ID:
 D010518
Disease NCIt ID:
 C34918
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

periodontal ligament tissues
Cell lines:

PDLSCs; PDLCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ERK
Associated microRNA: miR-7
Biological function: Mediates LPS-induced inhibition of PDLSC proliferation; CDR1as overexpression promotes PDLSC proliferation and partially alleviates LPS-induced proliferative inhibition, while CDR1as knockdown enhances proliferative inhibition.
Molecular mechanism: Acts as an miR-7 sponge to activate ERK signaling, linking CDR1as/miR-7 to ERK phosphorylation and PDLSC proliferation under LPS-induced inflammation.
Biological pathway or process:

ERK (promotes); proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

CDR1as is down-regulated in periodontitis periodontal ligament tissues and in LPS-treated PDLSCs. Functionally, CDR1as promotes PDLSC proliferation and counteracts LPS-induced proliferative inhibition by sponging miR-7 and activating ERK signaling.
Confidence score:

0.5546
Other information
Title:

circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition.

Journal: Mediators of inflammation
Published: 2019
PubMed ID: 31582895
Study type:

combined biological and clinical study
Data availability: No data were used to support this study.
Code availability: -