| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-455 |
| Biological function: |
circLRP6 promotes arsenite-induced EMT, malignant transformation, colony formation, migration, and invasion in T-HaCaT cells. |
| Molecular mechanism: |
circLRP6 acts as a cytoplasmic miR-455 sponge, thereby up-regulating the miR-455 target ZEB1 and inducing EMT during arsenite-induced malignant transformation. |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; IF (Immunofluorescence); Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circLRP6 is up-regulated during arsenite-induced malignant transformation of human HaCaT keratinocytes. It functions mainly in the cytoplasm as a miR-455 sponge, leading to increased ZEB1 expression and promotion of EMT, colony formation, migration, and invasion. |
| Confidence score: |
0.7909 |