| Expression pattern: |
UP |
| Associated gene: |
ATG7, Bax, Bcl-2 |
| Associated microRNA: |
miR-490-3p |
| Biological function: |
circ_0006948 promotes proliferation, migration and invasion of osteosarcoma Saos-2 cells; down-regulation of circ_0006948 reduces these abilities. |
| Molecular mechanism: |
circ_0006948 directly binds miR-490-3p and regulates ATG7 expression through miR-490-3p, forming a ceRNA-like circ_0006948/miR-490-3p/ATG7 regulatory mechanism. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0006948 expression increased with higher clinicopathological stage of osteosarcoma, suggesting possible relevance to disease progression. |
| Description: |
hsa_circ_0006948 is up-regulated in osteosarcoma tissues and Saos-2 cells. It promotes osteosarcoma cell proliferation, migration and invasion by targeting miR-490-3p and regulating ATG7 expression, and its expression increases with higher clinicopathological stage. |
| Confidence score: |
0.6829 |