| Expression pattern: |
UP |
| Associated gene: |
AKT, ERK½, mTOR, TFEB, LAMP2, ROS |
| Associated microRNA: |
miR-671-5p, hsa-miR-7, hsa-miR-1270 |
| Biological function: |
promotes autophagy; promotes cell survival/viability and proliferation; inhibits apoptosis; promotes tumor growth under hypoxia; promotes ER stress |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-671-5p to promote autophagy; enhances hypoxia-induced autophagy by activating AKT and ERK½ and inhibiting mTOR activity; increases lysosomal activity regulators (TFEB, LAMP2) and ROS under hypoxia |
| Biological pathway or process: |
autophagy (promotes); apoptosis (inhibits); proliferation (promotes); ERK (promotes); PI3K/AKT (promotes); PI3K/AKT/mTOR (inhibits); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
patients with a higher circCDR1as expression had shorter postoperative survival time than those with lower circCDR1as expression |
| Description: |
CircCDR1as is up-regulated in OSCC tissues/cell lines and further induced by hypoxia. It promotes OSCC cell survival and tumor growth by enhancing autophagy under hypoxia via AKT/ERK activation and mTOR inhibition, and acts as a sponge for miR-671-5p. High circCDR1as expression is associated with shorter postoperative survival. |
| Confidence score: |
0.7408 |