| Expression pattern: |
DN |
| Associated gene: |
IKKalpha |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; enhances cisplatin-induced pyroptosis; reduces tumorigenicity and metastasis |
| Molecular mechanism: |
circRNA encodes peptide/protein MAP3K13-232aa; MAP3K13-232aa binds IKKalpha kinase domain, increases IKKalpha activity, activates NF-kappaB signaling, upregulates NLRP3 and promotes pyroptosis |
| Biological pathway or process: |
NF-kappaB (promotes); pyroptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; circRNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Luciferase Reporter Assay; RNA Pull-Down; Co-IP; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
circMAP3K13 expression negatively correlates with tumor progression and shows diagnostic value for GC (AUC 0.7699) |
| Description: |
circMAP3K13 (hsa_circ_11430), derived from MAP3K13, is down-regulated in gastric cancer tissues/cell lines and suppresses malignant phenotypes. It functions largely by encoding the protein MAP3K13-232aa, which binds IKKalpha to activate NF-kappaB, upregulate NLRP3, and enhance (including cisplatin-induced) pyroptosis, reducing tumor growth and metastasis. |
| Confidence score: |
0.886 |