| Expression pattern: |
UP |
| Associated gene: |
CDK6, RPA3 |
| Associated microRNA: |
miR-597-5p, miR-145-5p, miR-30a-3p |
| Biological function: |
circ101555 promotes CRC cell proliferation, cell cycle progression, colony formation, DNA repair capacity and tumorigenesis, while inhibiting apoptosis; circ101555 knockdown suppresses these oncogenic phenotypes and induces apoptosis. |
| Molecular mechanism: |
circ101555 functions as a competing endogenous RNA and sponge of miR-597-5p, thereby up-regulating CDK6 and RPA3 expression in CRC. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; IF (Immunofluorescence); Western Blot; IHC (Immunohistochemistry); TUNEL; In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ101555 expression is associated with larger tumor size, lymph node metastases, advanced stage, distant metastases, worse 5-year overall survival and disease-free survival; circ101555 may serve as a prognostic indicator in CRC. |
| Description: |
circ101555 is up-regulated in CRC tissues and acts as an oncogenic circRNA. It promotes CRC progression by sponging miR-597-5p and increasing CDK6 and RPA3 expression, thereby enhancing proliferation, cell cycle progression, DNA repair and tumorigenesis while suppressing apoptosis. High circ101555 expression predicts poorer OS and DFS, supporting its potential as a prognostic biomarker and therapeutic target. |
| Confidence score: |
0.8942 |