circRNA basic information
circBase ID: hsa_circ_0091581
Name: hsa_circ_GPC3
Synonym: hsa_circRNA_091581
Host Gene: GPC3
Genomic location(hg19): chrX:132887508-132888203:-
Genomic location(hg38): chrX:133753481-133754176:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent normal liver tissues; paracancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCT5
Associated microRNA: has-miR-661
Biological function: unknown
Molecular mechanism: ceRNA network prediction (circRNA-miRNA-mRNA)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_091581 is up-regulated in HCC tissues versus adjacent tissues and was selected to build a predicted circRNA-miRNA-mRNA (ceRNA) network. In the hub-gene subnetwork, it is linked to miR-661 and the hub gene CCT5.
Confidence score:

0.6193
Other information
Title:

Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.

Journal: Frontiers in molecular biosciences
Published: 2022
PubMed ID: 35141281
Study type:

combined biological and clinical study
Data availability: GSE94508; GSE97332; GSE155949; GSE164803; TCGA-LIHC
Code availability: -