| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-203, hsa-miR-203a-5p |
| Biological function: |
Most likely associated with PHC and proposed as a PHC biomarker; postoperative decline may indicate association with transplanted liver without carcinoma recurrence. |
| Molecular mechanism: |
Predicted circRNA/miRNA adsorption mechanism involving miR-203; the study suggests hsa_circ_102347 regulates miRNA-related carcinoma recurrence after liver transplantation. |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Most likely to have association with PHC and proposed as a biomarker-associated PHC for adsorption mechanism. |
| Description: |
hsa_circ_102347 was significantly up-regulated in pre-transplantation peripheral blood from PHC patients compared with normal controls and decreased after liver transplantation to a level similar to normal controls by postoperative day 7. The study identifies it as the circRNA most likely associated with PHC, potentially acting through a miR-203-related adsorption/sponging mechanism and serving as a diagnostic biomarker. |
| Confidence score: |
0.5135 |