circRNA basic information
circBase ID: -
Name: hsa_circ_C3P1
Synonym: circC3P1
Host Gene: C3P1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent normal tissues; tumor tissues
Cell lines:

BEL7402; Hep3B; HuH7; MHCC97-L; HL-7702
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: PCK1
Associated microRNA: miR-4641
Biological function: circC3P1 acts as a tumor suppressor and inhibits HCC cell proliferation, migration, invasion, tumor growth and metastasis.
Molecular mechanism: circC3P1 promotes PCK1 expression by sponging miR-4641 in HCC cells.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
H
S
Validation methods:

circRNA-seq; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Survival Analysis; Bioinformatics Analysis
Clinical significance:

circC3P1 expression was negatively correlated with TNM stage, tumor size and vascular invasion, and circC3P1 may serve as a prognostic biomarker in HCC.
Description:

circC3P1 is a human C3P1-derived circRNA that is down-regulated in HCC tissues and cell lines. In this study, circC3P1 functions as a tumor suppressor by inhibiting HCC proliferation, migration, invasion, tumor growth and lung metastasis, at least partly through the circC3P1/miR-4641/PCK1 ceRNA axis. Clinically, circC3P1 expression correlates with TNM stage, tumor size, vascular invasion and survival, suggesting potential prognostic biomarker value.
Confidence score:

0.8057
Other information
Title:

Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway.

Journal: Biochemical and biophysical research communications
Published: 2018
PubMed ID: 29608893
Study type:

combined biological and clinical study
Data availability: GSE77661; GSE36376
Code availability: -