| Expression pattern: |
UP |
| Associated gene: |
CTNNB1, beta-catenin, MMP-7, MMP-9, C-Myc |
| Associated microRNA: |
miR-3619-5p |
| Biological function: |
circZFR acts as an oncogenic circRNA in HCC; its knockdown suppresses HCC cell proliferation and EMT process, while circZFR promotes HCC progression and poor prognosis. |
| Molecular mechanism: |
circZFR functions through a miR-3619-5p/CTNNB1 axis and activates the Wnt/beta-catenin pathway in HCC. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Western Blot; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis; Microarray |
| Clinical significance: |
High circZFR expression is associated with low overall survival rate and poor prognosis of HCC patients, suggesting potential as a therapeutic target. |
| Description: |
circZFR is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circZFR promotes HCC cell proliferation and EMT, and mechanistically it acts through the miR-3619-5p/CTNNB1 axis to activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.7325 |