| Expression pattern: |
UP |
| Associated gene: |
BMI-1 |
| Associated microRNA: |
miR-498 |
| Biological function: |
hsa_circ_0007534 acts as an oncogenic circRNA in cervical cancer; its depletion represses cervical cancer cell proliferation, colony formation, and invasion. |
| Molecular mechanism: |
hsa_circ_0007534 competitively binds miR-498, relieves miR-498-mediated suppression of BMI-1, and thereby upregulates BMI-1 expression to promote cervical cancer cell proliferation and invasion. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0007534 may serve as a potential therapeutic target for cervical cancer. |
| Description: |
hsa_circ_0007534 is upregulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses cervical cancer cell proliferation, colony formation, and invasion by increasing miR-498 and reducing BMI-1 expression through the hsa_circ_0007534/miR-498/BMI-1 axis, suggesting therapeutic relevance. |
| Confidence score: |
0.7032 |