| Expression pattern: |
DN |
| Associated gene: |
NFATC2IP |
| Associated microRNA: |
hsa-miR-1298-3p, hsa-miR-660-3p |
| Biological function: |
May function as a tumor suppressor gene in osteosarcoma and may be involved in osteosarcoma initiation and progression. |
| Molecular mechanism: |
Predicted ceRNA mechanism: hsa_circRNA_104980 may interact with hsa-miR-1298-3p and hsa-miR-660-3p and was correlated with the predicted ceRNA NFATC2IP; bioinformatics analyses associated it with tight junction, IFN-beta enhancer, p38, asparagine N-linked glycosylation and cytokine signaling in immune system pathways. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May serve as a biomarker of osteosarcoma diagnosis and treatment or a potential diagnostic biomarker/therapeutic target. |
| Description: |
hsa_circRNA_104980 is down-regulated in osteosarcoma cell lines and tissues. The study suggests it may act as a tumor suppressor circRNA and predicts a circRNA/miRNA/mRNA regulatory network involving hsa-miR-1298-3p, hsa-miR-660-3p and the correlated downstream partner NFATC2IP. Bioinformatics analyses associated it with tight junction and immune/cytokine-related pathways, but the authors note that further validation is needed. |
| Confidence score: |
0.4032 |