| Expression pattern: |
UP |
| Associated gene: |
TANC1 |
| Associated microRNA: |
hsa-miR-370-3p, hsa-miR-338-3p, hsa-miR-877-3p |
| Biological function: |
May act as an oncogene in osteosarcoma and may promote osteosarcoma initiation, progression and metastasis. |
| Molecular mechanism: |
Predicted ceRNA mechanism: hsa_circRNA_103801 may bind target miRNAs and increase expression of downstream mRNAs such as TANC1; it was also linked by bioinformatics analyses to HIF-1, VEGF, angiogenesis, Rap1 and PI3K-Akt signaling pathways. |
| Biological pathway or process: |
ceRNA regulation (promotes); HIF-1 signaling (promotes); VEGF/VEGFR (promotes); angiogenesis (promotes); metastasis (promotes); PI3K/AKT (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May serve as a biomarker of osteosarcoma diagnosis and treatment or a potential diagnostic biomarker/therapeutic target. |
| Description: |
hsa_circRNA_103801 is up-regulated in osteosarcoma cell lines and tissues. The study predicts that it may function as an oncogenic ceRNA by interacting with hsa-miR-370-3p, hsa-miR-338-3p and hsa-miR-877-3p, with TANC1 as a correlated downstream ceRNA partner. Bioinformatics analyses linked it to HIF-1, VEGF/angiogenesis, Rap1 and PI3K-Akt-related pathways, suggesting potential diagnostic or therapeutic relevance. |
| Confidence score: |
0.4032 |