circRNA basic information
circBase ID: hsa_circ_0023990
Name: hsa_circ_NOX4
Synonym: -
Host Gene: NOX4
Genomic location(hg19): chr11:89165951-89185063:-
Genomic location(hg38): chr11:89432783-89451895:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent non-tumorous tissues / paired normal mucosa
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NOX4, SOX1, AQP6, ITGBL1
Associated microRNA: -
Biological function: potential roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network; associated with improved survival when highly expressed
Molecular mechanism: ceRNA mechanism linking to mRNAs (SOX1, AQP6, ITGBL1) (bioinformatics-described)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

circRNA-seq; RNA-seq; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis
Clinical significance:

high expression improves survival time in patients with CRC; candidate diagnostic biomarkers or potential therapeutic targets (as a group of circRNAs)
Description:

hsa_circ_0023990 is up-regulated in colorectal cancer and originates from NOX4. In the study’s predicted ceRNA context, higher hsa_circ_0023990 expression is associated with longer survival time, linked to higher expression of SOX1, AQP6 and ITGBL1.
Confidence score:

0.559
Other information
Title:

Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.

Journal: PeerJ
Published: 2019
PubMed ID: 31579577
Study type:

combined biological and clinical study
Data availability: PRJNA521856
Code availability: -