| Expression pattern: |
UP |
| Associated gene: |
TMED5 |
| Associated microRNA: |
miR-183-5p |
| Biological function: |
promotes cell proliferation, suppresses apoptosis, promotes angiogenesis, and promotes tumor growth in cervical cancer |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-183-5p to induce TMED5 expression (ceRNA mechanism), thereby promoting cervical carcinogenesis and angiogenesis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Tube Formation Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0018289 is up-regulated in cervical cancer and acts as an oncogenic circRNA. It promotes proliferation, inhibits apoptosis, enhances angiogenesis and tumor growth by sponging miR-183-5p to derepress TMED5 (circ_0018289/miR-183-5p/TMED5 axis). |
| Confidence score: |
0.7859 |