| Expression pattern: |
UP |
| Associated gene: |
FOXR2, beta-catenin, c-Myc, HK-2, MMP9, E-cad |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
Circ-PGC functions as an oncogene in NSCLC, promoting cell viability, colony formation, migration, invasion, glycolysis metabolism and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
Circ-PGC acts as a ceRNA/molecular sponge for miR-532-3p to positively regulate FOXR2 expression, activating the Wnt/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-PGC expression was associated with poor overall survival of NSCLC patients within 5 years. |
| Description: |
Circ-PGC is up-regulated in NSCLC tissues and cell lines and high expression is associated with poor overall survival. Functionally, circ-PGC promotes NSCLC cell proliferation, migration, invasion, glycolysis and in vivo tumor growth, while suppressing apoptosis. Mechanistically, circ-PGC sponges miR-532-3p to increase FOXR2 expression and may activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.8175 |