| Expression pattern: |
UP |
| Associated gene: |
ACSL4, AGO2 |
| Associated microRNA: |
miR-3667-3p |
| Biological function: |
Promotes HSC activation and proliferation, elevates inflammation, and inhibits apoptosis in liver fibrosis model cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-3667-3p to relieve repression of ACSL4, implicating ferroptosis-related changes. |
| Biological pathway or process: |
proliferation (promotes); inflammation (promotes); apoptosis (inhibits); ferroptosis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; FISH / smFISH; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; ELISA; Western Blot; Annexin V/PI Flow Cytometry |
| Clinical significance: |
Potential therapeutic target for liver fibrosis. |
| Description: |
hsa_circ_0074763 is up-regulated in liver fibrosis models and promotes HSC activation by acting as a ceRNA that sponges miR-3667-3p, thereby relieving repression of ACSL4. Functionally, it increases LX-2 proliferation and inflammatory markers and reduces apoptosis, linking the axis to ferroptosis-associated readouts. |
| Confidence score: |
0.7548 |