| Expression pattern: |
UP |
| Associated gene: |
RAB32 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes CRC cell proliferation and inhibits apoptosis (tumor-promoting factor); knockdown inhibits proliferation and promotes apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-338-3p to upregulate RAB32. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
ROC curve analysis indicated circ_0039857 has diagnostic value for CRC (AUC = 0.9513). |
| Description: |
circ_0039857 is up-regulated in colorectal cancer tissues and cell lines and shows diagnostic potential by ROC analysis. Functionally, circ_0039857 promotes CRC malignant progression by enhancing proliferation and inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-338-3p to increase RAB32 expression. |
| Confidence score: |
0.8287 |