circRNA basic information
circBase ID: hsa_circ_0020397
Name: hsa_circ_DOCK1
Synonym: circ_0020397
Host Gene: DOCK1
Genomic location(hg19): chr10:128768965-128926028:+
Genomic location(hg38): chr10:126970701-127127764:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

CCD 841 CoN; LoVo; HCT116; SW480; SW620
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TERT, PD-L1
Associated microRNA: miR-138
Biological function: Promotes CRC cell viability and invasion and inhibits apoptosis; antagonizes miR-138 suppression of cell growth.
Molecular mechanism: hsa_circ_0020397 sequesters miR-138, inhibits miR-138 activity, and thereby promotes expression of the miR-138 target genes TERT and PD-L1.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay
Clinical significance:

-
Description:

hsa_circ_0020397 is up-regulated in colorectal cancer cells. It acts as a miR-138 sponge to inhibit miR-138 function and increase expression of the miR-138 targets TERT and PD-L1, thereby promoting CRC cell viability and invasion while inhibiting apoptosis.
Confidence score:

0.5607
Other information
Title:

Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1.

Journal: Cell biology international
Published: 2017
PubMed ID: 28707774
Study type:

biological research
Data availability: -
Code availability: -