circRNA basic information
circBase ID: hsa_circ_0001982
Name: hsa_circ_RNF111
Synonym: circRNA RNF111 / circ‐0001982
Host Gene: RNF111
Genomic location(hg19): chr15:59323002-59323901:+
Genomic location(hg38): chr15:59030803-59031702:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; histologically normal tissues
Cell lines:

hFOB1.19; MG63; MG63/Dox; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-143
Biological function: promotes proliferation, colony formation, migration, invasion, and multidrug resistance/chemoresistance in osteosarcoma cells; knockdown reduces doxorubicin resistance
Molecular mechanism: targets/binds (sponges) miR-143 and negatively regulates miR-143 expression; proposed ceRNA-like mechanism without downstream mRNA validated
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay
Clinical significance:

hsa_circ_0001982 is a potential target for early diagnosis and targeted therapy of OS
Description:

hsa_circ_0001982 is up-regulated in osteosarcoma tissues/cells and further increased in chemoresistant samples. Functionally, it promotes proliferation, colony formation, migration/invasion and multidrug resistance in OS cells, and it can directly bind miR-143 and negatively regulate miR-143 expression, supporting a circRNA/miRNA regulatory mechanism.
Confidence score:

0.6479
Other information
Title:

Hsa_circ_0001982 promotes the proliferation, invasion, and multidrug resistance of osteosarcoma cells.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35576496
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -