| Expression pattern: |
UP |
| Associated gene: |
MMP16, AGO2 |
| Associated microRNA: |
miR-193a-5p |
| Biological function: |
promotes proliferation, migration, and invasion of HCC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0001806 sponges miR-193a-5p to up-regulate MMP16 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
potential biomarker and therapy target for HCC |
| Description: |
circ_0001806 is overexpressed in HCC tissues and cell lines and promotes HCC cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-193a-5p to relieve repression of MMP16, thereby driving malignant behaviors. |
| Confidence score: |
0.8035 |