circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_000839 / circ_000839
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

hepatocellular cancer tissues; adjacent normal liver tissues; HCC tissue; normal liver tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RhoA
Associated microRNA: miR-200b
Biological function: circ_000839 was up-regulated in HCC tissues and correlated inversely with miR-200b and positively with RhoA; its direct role in HCC mobility and invasion was not investigated in this study.
Molecular mechanism: Predicted miR-200b-associated endogenous competition involving circ_000839 and RhoA, supported by expression correlation analyses.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_000839 was identified as a predicted miR-200b target circRNA and was significantly up-regulated in HCC tissues compared with normal liver tissues. Its expression was negatively correlated with miR-200b and positively correlated with RhoA, supporting a proposed miR-200b-mediated endogenous competition model involving circ_000839 and RhoA, although the direct functional role of circ_000839 in HCC invasion or migration was not tested.
Confidence score:

0.348
Other information
Title:

MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Published: 2017
PubMed ID: 28695771
Study type:

combined biological and clinical study
Data availability: Any underlying research materials related to this paper (for example, data, samples, or models) can be accessed.
Code availability: -