| Expression pattern: |
UP |
| Associated gene: |
MDM4, p53, Ago2 |
| Associated microRNA: |
miR-150-5p |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, tumor growth and lung metastasis; inhibits apoptosis; promotes cell cycle progression by reducing G1-phase blockade. |
| Molecular mechanism: |
Acts as a competing endogenous RNA sponge for miR-150-5p, thereby regulating MDM4 expression and affecting p53 expression in cervical cancer. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); cell cycle (promotes); metastasis (promotes); p53 signaling (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
The study suggests potential clinical significance for diagnosis and treatment of future cervical cancer, but no patient diagnostic or prognostic validation was reported. |
| Description: |
hsa_circ_0000263 is up-regulated in cervical cancer cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, tumor growth and lung metastasis while inhibiting apoptosis, at least partly through the hsa_circ_0000263/miR-150-5p/MDM4/p53 regulatory network. |
| Confidence score: |
0.7898 |