| Expression pattern: |
UP |
| Associated gene: |
ribosomes, Argonaute 2 protein |
| Associated microRNA: |
- |
| Biological function: |
Candidate association with ribosomes and Argonaute 2 suggests a possible role in translation regulation; disease-context functional effects were not directly tested. |
| Molecular mechanism: |
Host gene-independent expression in DCM; candidate association with ribosomes and Argonaute 2 protein |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
Significant change in circRNA abundance in DCM patients compared with non-failing controls |
| Description: |
circSLC8A1 was significantly increased relative to its host gene expression in DCM heart samples compared with non-failing controls. Homolog-based RIP analyses also suggested association with ribosomes and Argonaute 2, implying a possible role in translation regulation. |
| Confidence score: |
0.2995 |