| Expression pattern: |
UP |
| Associated gene: |
B7H3 |
| Associated microRNA: |
miR-15a-5p |
| Biological function: |
circFARSA promotes NSCLC tumorigenesis and development, facilitates cell proliferation, migration, invasion, tumor growth and metastasis, and its knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
circFARSA acts as a ceRNA sponge for miR-15a-5p, thereby upregulating B7H3 expression to promote malignant phenotypes in NSCLC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circFARSA expression was positively associated with TNM stage, tumor size, lymph node metastasis, and poor overall survival; circFARSA may serve as a novel therapeutic target for NSCLC. |
| Description: |
circFARSA/hsa_circ_0000896 is upregulated in NSCLC tissues and cell lines and high expression is associated with adverse clinicopathological features and poorer overall survival. Functionally, circFARSA promotes NSCLC cell proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, it acts as a cytoplasmic sponge for miR-15a-5p to increase B7H3 expression, forming a circFARSA/miR-15a-5p/B7H3 oncogenic axis. |
| Confidence score: |
0.817 |