circRNA basic information
circBase ID: hsa_circ_0127801
Name: hsa_circ_LMNB1
Synonym: -
Host Gene: LMNB1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissue; adjacent tissue / para-carcinoma tissues
Cell lines:

LoVo; HCT116; HT29; SW480; RKO; FHC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: E-cadherin, Bax, caspase-3, MMP2, MMP-9, N-cadherin
Associated microRNA: -
Biological function: promotes cell proliferation, migration and invasion; inhibits apoptosis; promotes EMT
Molecular mechanism: Regulation of EMT- and apoptosis-related proteins (E-cadherin, N-cadherin, MMP2/9, Bax, caspase-3) following circLMNB1 knockdown/overexpression
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation
Clinical significance:

suggests circLMNB1 as a novel biomarker for CRC
Description:

circLMNB1 (hsa_circ_0127801, from LMNB1) is up-regulated in colorectal cancer tissues and CRC cell lines. Functional assays show that circLMNB1 promotes malignant phenotypes (proliferation, migration/invasion, EMT) and suppresses apoptosis, partly accompanied by changes in EMT/apoptosis-related proteins (E-cadherin, N-cadherin, MMP2/9, Bax, caspase-3). It is proposed as a potential diagnostic biomarker for CRC.
Confidence score:

0.7099
Other information
Title:

CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31496737
Study type:

combined biological and clinical study
Data availability: -
Code availability: -