| Expression pattern: |
DN |
| Associated gene: |
AGO2, EIF4A3, LIN28A, IGF2BP1, PTB |
| Associated microRNA: |
miR-1248, miR-766 |
| Biological function: |
Underexpressed in RR-MS peripheral blood and proposed as a blood biomarker for multiple sclerosis; no disease functional assays were reported. |
| Molecular mechanism: |
Bioinformatic prediction of miRNA binding sites and RNA-binding protein binding sites; possible involvement in transcriptome regulation, parental gene expression regulation, or RBP interaction. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential blood biomarker for RR-MS; ROC AUC 0.899 with p-value < 0.001, sensitivity 94.4%, and specificity 75.0%. |
| Description: |
circ_0005402 is a human ANXA2-derived circRNA that is significantly downregulated in peripheral blood from RR-MS patients. Its expression showed biomarker potential for RR-MS with a significant ROC AUC of 0.899, and bioinformatic analysis predicted miRNA and RBP binding sites. |
| Confidence score: |
0.6841 |